Anti-TPO Antibody Blood Test – Hashimoto’s & Graves’ Screening
Detect anti-thyroid peroxidase antibodies that signal autoimmune thyroiditis. Free home collection • NABL-accredited labs • Fast digital reports.
Offer Price ₹999 | MRP ₹1500
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Specifications of Anti-TPO Test
| Parameter | Details |
|---|---|
| Test Name | Anti-TPO (Anti-Thyroid Peroxidase Antibodies), also called Anti-microsomal Antibodies (AMA) |
| Technology | CLIA (Chemiluminescent Immunoassay) |
| Units | IU/mL |
| Reference Range | Negative: < 9 | Positive: ≥ 9 |
| Analytical Performance | Precision: Intra-assay %CV ≈ 7.1%, Inter-assay %CV ≈ 4.40%; Sensitivity ≈ 0.25 IU/mL |
| Sample Type | Serum (venous blood) |
| Fasting | Not required |
| Turnaround Time | Usually 24–48 hours (city dependent) |
| Accreditation | NABL-accredited & ISO-certified partner labs |
Clinical Significance (original content retained)
Microsomes are found inside thyroid cells. The body produces antibodies against microsomes when there has been some damage caused to thyroid cells. Autoimmunity induces the immune system to produce antibodies against host tissue causing inflammation or impairing thyroid function. Presence of anti-microsomal antibody (AMA) is generally associated with autoimmune disorder. A positive test for AMA can indicate Hashimoto’s thyroiditis or granulomatous thyroiditis or Rheumatoid arthritis or Autoimmune hemolytic anemia (rarely) etc.
Specifications: Precision: Intra assay (%CV): 7.1%, Inter assay (%CV): 4.40%; Sensitivity: 0.25 IU/mL
Kit Validation reference: Kimura S, Kotani T, McBride OW, Umeki K, Hiral, Nakayama T. Human thyroid peroxidase complete cDNA and protein sequence, chromosome mapping and identification of two alternately spliced mRNAs. Proc Natl Acad Sci. 1987.
Sample Report: Anti-TPO test sample report
What is the Anti-TPO Test?
Anti-TPO Test, also known as the Anti-Thyroid Peroxidase Antibody Test (or Anti-microsomal Antibody test), detects antibodies against the enzyme thyroid peroxidase, which is essential for thyroid hormone synthesis. Persistently elevated Anti-TPO suggests an autoimmune process that can damage thyroid tissue and alter hormone production, most commonly seen in Hashimoto’s thyroiditis (hypothyroidism) and sometimes in Graves’ disease (hyperthyroidism).
Why is the Anti-TPO Test done?
- To detect Hashimoto’s thyroiditis—a leading cause of hypothyroidism
- To support diagnosis/monitoring of Graves’ disease
- To evaluate unexplained symptoms like fatigue, weight change, mood swings, menstrual irregularities
- To assess pregnancy-related thyroid risk or postpartum thyroiditis
- To screen those with family history of thyroid/autoimmune disease
Who should consider testing?
- People with persistent tiredness, low mood/anxiety, cold/heat intolerance, hair thinning, dry skin
- Unexplained weight gain or loss
- Neck swelling (possible goitre)
- Irregular cycles, subfertility, or pregnancy planning
- Personal/family history of autoimmune disorders
How is it performed?
It is a simple venous blood test. No fasting is required. Labs quantify Anti-TPO antibodies and report them in IU/mL using CLIA methodology.
How to interpret results?
- Low/undetectable: No evidence of active thyroid autoimmunity
- Elevated: Suggests autoimmune thyroiditis—interpret with TSH, Free T4, (± Free T3), and sometimes Anti-Thyroglobulin (Anti-Tg)
Note: Elevated antibodies alone do not mandate treatment; your clinician will correlate with symptoms, ultrasound, and thyroid function tests.
Practical Guidance & Pre-Test Considerations
| Topic | Key Points |
|---|---|
| Best Companion Tests | TSH, Free T4 (± Free T3); consider Anti-Tg antibodies; ultrasound if goitre/nodules suspected |
| Interferences | High-dose biotin supplements may affect some immunoassays—stop for ~48 hours unless advised otherwise |
| Pregnancy | Anti-TPO positivity increases risk of thyroid dysfunction; closer monitoring may be advised during and after pregnancy |
| Follow-up | Repeat testing is usually not frequent; monitor thyroid function (TSH/FT4) per clinician’s advice |
| Lifestyle | Maintain iodine-adequate diet; discuss selenium intake and vitamin D if deficient; manage stress and sleep |
Plan your test
Anti-TPO Price & Booking
- Offer Price: ₹999 (MRP ₹1500)
- Home Collection: Free in serviceable PIN codes
- Reports: Secure digital delivery
Nationwide Coverage
Available across major metros and tier-2/3 cities including Bengaluru, Chennai, Delhi-NCR, Hyderabad, Kolkata, Mumbai, Pune, Ahmedabad, Jaipur, Lucknow, Chandigarh, Bhopal, Indore, Nagpur, Patna, Ranchi, Bhubaneswar, Guwahati, Surat, Vadodara, Rajkot, Nashik, Thane, Varanasi, Kanpur, Prayagraj, Jodhpur, Udaipur, Dehradun, Mysuru, Mangaluru, Coimbatore, Madurai, Kochi, Trivandrum, Salem, Vijayawada, Visakhapatnam, Warangal, Hubballi-Dharwad, Belagavi, Tiruchirappalli, Puducherry, and more.
Healthcare Offers Advantage
- NABL-accredited & ISO-certified partner labs
- Doorstep phlebotomy with proper biosafety & barcoding
- Transparent pricing, reliable CLIA methodology
- Doctor-trusted workflows and fast TAT
Why is the Anti-TPO Test done?
This test helps in identifying autoimmune thyroid conditions and plays an important role in:
- Detecting Hashimoto’s thyroiditis (a common cause of hypothyroidism)
- Diagnosing and monitoring Graves’ disease (linked with hyperthyroidism)
- Evaluating unexplained symptoms like fatigue, weight changes, mood swings, and irregular menstrual cycles
- Investigating thyroid issues during pregnancy or postpartum
- Assessing thyroid health in individuals with a family history of thyroid or autoimmune disorders
Who should get the Anti-TPO Test?
Your doctor may recommend this test if you experience:
- Constant tiredness, depression, or anxiety
- Unexplained weight gain or loss
- Hair thinning, dry skin, or cold/heat intolerance
- Swelling in the neck (possible goiter)
- Fertility issues or irregular periods
- History of thyroid issues or autoimmune diseases in the family
- Pregnancy-related thyroid concerns
How is the Anti-TPO Test performed?
The Anti-TPO Test is a simple blood test. A small sample is taken from a vein in your arm. No fasting or special preparation is required before the test. The blood sample is analyzed to measure the level of anti-TPO antibodies.
Understanding Anti-TPO Test results
- Low or undetectable levels: Generally considered normal, with no active autoimmune response.
- Elevated levels: Suggest an autoimmune attack on the thyroid, indicating the possibility or presence of a thyroid disorder.
High antibody levels alone don’t always mean you need treatment, but they do help your doctor evaluate the risk and guide further diagnosis or monitoring.
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