Non Invasive Prenatal Testing (NIPT) in Jamshedpur

NIPT Screeing Panel in Jamshedpur at ₹11,499 Only

NIPT Test in Jamshedpur: You May Need to Know

Methodology

NIPT screens a maternal blood sample for chromosomal aneuploidy in fetal DNA using the following methodology:

• Extraction of fetal cell-free DNA from the maternal blood sample
• High throughput sequencing of the extracted fetal cell-free DNA
• Calculation of molecular mass of fetal DNA in all chromosomes

Reporting Conditions

Based on the scope, NIPT can screen the following conditions:

• Whole Genome – 23 pairs of human chromosomes
  • Common Chromosomal abnormality: Trisomy 13 (Patau’s Syndrome) Trisomy 18 (Edwards’ Syndrome) Trisomy 21 (Down’s Syndrome)

NIPT is capable of genome-wide aneuploidy detection of the whole fetal genome (23 pairs of chromosomes). Test results with the interpretation of risk for Trisomy 13 Trisomy 18, Trisomy 21 and sex chromosome aneuploidies will be provided. This test conversant accuracy of up to 99% on the detection of fetal chromosomal aneuploidy.

Why NIPT?

The advantage of an NIPT screening blood tests are as follows:

• We can save 6% to 7% unburn babies from congenital abnormalities
• No risk to the mother or the unborn child
• High sensitivity and specificity
• Early detection of chromosomal disorder
• Far better than a Double or Triple Marker test panel
• Latest technology like the Next Generation Sequencing

About NIPT Near You

YES-IN-GENE specializes in research development and high-quality professional services in clinical genetic testing. NIPT analyzes circulating fetal cell-free DNA extracted from a maternal blood sample, and is offered to pregnant women with a pre-test risk of aneuploidy in chromosomes such as 13, 18, 21, X or Y. The chance that a fetus is affected with chromosomal aneuploidy can be estimated using bioinformatics analyses, by which the accuracy rate and sensitivity are over 99%. The accuracy and quality of the test may be affected by low fetal fraction, high data noise due to improper blood sample collection, handling, storage, or transportation.

If you are looking for an NIPT screening service location near you in Jamshedpur, West Singhbhum, Jharkhand, you may contact at +91 88777 26781 for further details.

Limitations of the NIPT Test

Non-invasive prenatal testing should only be considered a screening test. The screening test of fetal cell-free DNA cannot compare with the prenatal diagnosis with Amniocentesis or Chorionic Villus Sampling (CVS). Pregnant women with a positive NIPT screening result should be given an invasive prenatal diagnosis and referred further for genetic counselling to confirm conditions. On the other hand, a negative test result does not ensure an unaffected pregnancy. Even though NIPT provides reliable results, it does not apply to all cases of chromosomal abnormalities, for example, cases due to placental, maternal, or fetal mosaicism, or other causes (e.g. micro-deletions, chromosome re-arrangements, translocations, inversions, unbalanced translocations, uniparental disomy, etc.). NIPT is also not applicable for cases with a diagnosed multiple gestation, or with gestational age that is less than 10 weeks. In rare cases when a borderline screening result is reported, retesting is required to confirm conditions.

Which Test to Do When? NIPT or the Other?

Prenatal Screening Time Lines and Tests

1. Depending on your age, weight, clinical history, and lifestyle, your healthcare advisor may suggest you a double markers panel in 9th to 13th week of pregnancy, or triple or quadruple markers profile in 14th to 20th week of pregnancy. These tests screens for Down, Edwards, and Patau Syndromes with the help of an NT Scan USG
2. In case any of three syndromes as mentioned above or a Neural Tube Defect is suspected in the screening, your healthcare consultant may ask you to go through a Basic NIPT Screening or an Advanced NIPT Screening with Microdeletion.
3. In case an NIPT basic or NIPT Microdeletion Advanced panel shows any abnormality, your doctor may ask you to go for a Chorionic Villus Sampling during the first trimester of pregnancy. If it is the second trimester of your pregnancy, you need an Ammonitic Flued Karyotype testing.

NIPT: Test Method

NIPT applies a non-invasive and low-risk procedure to collect fetal DNA samples. Circulating fetal cell-free DNA is purified from the plasma component of 10mL anti-coagulated maternal whole blood. It is then converted into a genomic DNA library for Next Generation Sequencing to determine Trisomy 21, 18 and 13 and other chromosomal abnormalities.

How Does an NIPT Report look likes?

Here is a sample visual image of NIPT report:

The above are screenshots of a three page images of an NIPT report. The images are just for information purpose only. None of these is for a referral purpose.

Different Types of NIPT Screening Tests in Jamshedpur

In Jamshedpur or any location near to Jamshedpur in the district of East Singhbhun, Jhaerkhand, you can find two different layers of NIPT for chromosomal risk analysis as follows:

1. Non Invasive Prenatal Testing (NIPT) Basic
2. Non Invasive Prenatal Testing (NIPT) Advanced with Microdeletion

The second one costs in around twice of the first as laboratory expenditures increases more than twice. An advanced NIPT with microdeletion cab be more helpful in reading the result due to more micro-level testing.

Relevant Blood Tests in Jamshedpur

The following are the blood and urine tests panels other than the NIPT that you may need during your pregnancy period. These test profiles can help you in save pregnancy, healthy child birth, and riskless parenting.

• Antenatal Care (ANC) Profiles
• Double Marker Test Panel
• Triple Marker Test Panel
• TORCH Panels
• Preeclampsia Profiles

References: NIPT

For Doctors

1. ObstetGynecol 2012; 119:890-901.
2. BMJ 2011; 342:c7401.
3. PrenatDiagn 2012; 32:c7401.
4. ACOG/SMFM Joint Committee Opinion No. 545, Dec 2012.

For Patients

1. NIPT – Mediline Plus
2. NIPT Test – Cleveland Clinic

Know your NIPT Test

A Noninvasive Prenatal testing or Noninvasive Prenatal Screening is neither a routine blood test or a common pregnancy profile tests. It is a special test that your doctor may ask to go through in some specific circumstances. So you may have many queries regarding the NIPT screening. Here are answers tp some frequently asked queries that may be helpful to you.

Statutory Information and Declaration

We strictly follow the legal provisions of NIPT screening in India. Any type of gender detection test is strictly prohibited and we fully abide by the same guidelines and regulations by the Government of India. We Also strictly discourse such practices in India. All the genetic study, chromosomal defection study, hereditary abnormality study advertised us comes under legal provisions and we do not violate anything knowingly.

We also declare that all the information here are for informative purpose only. The suggestion of an certified medical practitioner should be considered as final.

We strongly believe that none of the information provided here is misleading, violating any legal provision, or violating the rigorous principle of clinical testing.

By mentioning the limitations of NIPT, we honor the principle of medical sciences, and stopping ourselves from creating any misconception.

Most of the information provided here is a summery of the information provided by the testing labs only. We just summarized the same with due reference for only the purpose of comprehensiveness.

We agree to change the content at anytime with input from a registered medical practitioner, or a valid medical association, or the concerned governmental authority.