Anti-TPO antibody (Anti-Thyroid Peroxidase) Blood Test

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Specifications of Anti-TPO Test

Technology:  C.L.I.A
Reference Range :-
Negative : < 9
Positive : >=9

Unit:  IU/mL

Clinical Significance:

Microsomes are found inside thyroid cells. The body produces antibodies against microsomes when there has been some damage
caused to thyroid cells. Autoimmunity induces the immune system to produce antibodies against host tissue causing inflammation
or impairing thyroid function .Presence of anti-microsomal antibody (AMA) is generally associated with autoimmune disorder.A
positive test for AMA can indicate Hashimoto’s thyroiditis or granulomatous thyroiditis or Rheumatoid arthritis or
Autoimmune hemolytic anemia (rarely) etc.
Specifications: Precision: Intra assay (%CV): 7.1%, Inter assay (%CV): 4.40%; Sensitivity: 0.25IU/mL
Kit Validation reference:
Kimura S Kotani T Mc Bride OW Umeki K Hiral Nakayama T .Human thyroid peroxidase complete cDNA and protein sequence
chromosome mapping and identification of two alternately spliced mRNAs. Proc Natl Acad Sci 1987.

Sample Report: Anti-TPO test sample report

Anti-TPO Test, also known as the Anti-Thyroid Peroxidase Antibody Test or Anti-microsomal Antibody (AMA) test, is a diagnostic blood test used to detect antibodies against thyroid peroxidase – an enzyme crucial for the production of thyroid hormones. The presence of these antibodies typically indicates an autoimmune response, which may lead to thyroid disorders such as Hashimoto’s thyroiditis or Graves’ disease.

Why is the Anti-TPO Test done?

This test helps in identifying autoimmune thyroid conditions and plays an important role in:

• Detecting Hashimoto’s thyroiditis (a common cause of hypothyroidism)

• Diagnosing and monitoring Graves’ disease (linked with hyperthyroidism)

• Evaluating unexplained symptoms like fatigue, weight changes, mood swings, and irregular menstrual cycles

• Investigating thyroid issues during pregnancy or postpartum

• Assessing thyroid health in individuals with a family history of thyroid or autoimmune disorders

Who should get the Anti-TPO Test?

Your doctor may recommend this test if you experience:

• Constant tiredness, depression, or anxiety

• Unexplained weight gain or loss

• Hair thinning, dry skin, or cold/heat intolerance

• Swelling in the neck (possible goiter)

• Fertility issues or irregular periods

• History of thyroid issues or autoimmune diseases in the family

• Pregnancy-related thyroid concerns

How is the Anti-TPO Test performed?

The Anti-TPO Test is a simple blood test. A small sample is taken from a vein in your arm. No fasting or special preparation is required before the test. The blood sample is analyzed to measure the level of anti-TPO antibodies.

Understanding Anti-TPO Test results

• Low or undetectable levels: Generally considered normal, with no active autoimmune response.

• Elevated levels: Suggest an autoimmune attack on the thyroid, indicating the possibility or presence of a thyroid disorder.

High antibody levels alone don’t always mean you need treatment, but they do help your doctor evaluate the risk and guide further diagnosis or monitoring.

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